RNA Details
Disease Name
pulmonary hypertension
Tissue
lung
RNA Symbol
miR-648
RNA ID
RNA Type
miRNA
Alteration Pattern
down regulation
Species
homo sapiens
Detection Methods
Northern blot; qRT-PCR etc.
Target
ET-1
Pathway
NA
PubMed ID
Title
MicroRNA 648 Targets ET-1 mRNA and Is Cotranscriptionally Regulated with MICAL3 by PAX5
Year
2015
Function
"MiR-648 targets the 3' UTR of ET-1 mRNA; MiR-648 is located in a 5'-proximal intron of MICAL3, and was under positive control by PAX5 with MICAL3. PlGF-mediated downregulation of PAX5 attenuates miR-648 expression leading to increased ET-1 levels that are known to induce PHT in SCA."